3LAQ

Structure-based engineering of species selectivity in the uPA-uPAR interaction

Summary for 3LAQ

Entry DOI	10.2210/pdb3laq/pdb
Related	2FAT 2FD6 3BT1 3BT2
Descriptor	Urokinase-type plasminogen activator, Urokinase plasminogen activator surface receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	upa, upar, atf, supar, smupar, matf, disulfide bond, egf-like domain, hydrolase, kringle, plasminogen activation, protease, secreted, serine protease, zymogen, cell membrane, glycoprotein, gpi-anchor, lipoprotein, membrane, receptor, hydrolase-hydrolase receptor complex, hydrolase/hydrolase receptor
Biological source	Mus musculus (mouse) More
Total number of polymer chains	4
Total formula weight	92549.57
Authors	Huang, M. (deposition date: 2010-01-06, release date: 2010-02-02, Last modification date: 2020-07-29)
Primary citation	Lin, L.,Gardsvoll, H.,Huai, Q.,Huang, M.,Ploug, M. Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J.Biol.Chem., 285:10982-10992, 2010 Cited by PubMed: 20133942 DOI: 10.1074/jbc.M109.093492 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation