3L9J

Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex

Summary for 3L9J

• Entry DOI: 10.2210/pdb3l9j/pdb
• Descriptor: TNFalpha, Tumor necrosis factor, soluble form, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: tnf-alpha, antagonist, in vitro selection, cell membrane, cytokine, disulfide bond, glycoprotein, lipoprotein, secreted, signal-anchor, transmembrane, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane ; Single-pass type II membrane protein . Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted. C-domain 2: Secreted: P01375
• Total number of polymer chains: 2
• Total formula weight: 31836.15

Authors

Byla, P.,Andersen, M.H.,Thogersen, H.C.,Gad, H.H.,Hartmann, R. (deposition date: 2010-01-05, release date: 2010-02-23, Last modification date: 2023-11-01)

• Primary citation: Byla, P.,Andersen, M.H.,Holtet, T.L.,Jacobsen, H.,Munch, M.,Gad, H.H.,Thogersen, H.C.,Hartmann, R.; Selection of a novel and highly specific TNF{alpha} antagonist: insight from the crystal structure of the antagonist-TNF{alpha} complex; J.Biol.Chem., 285:12096-12100, 2010; PubMed: 20179326; DOI: 10.1074/jbc.M109.063305

Experimental method

X-RAY DIFFRACTION (2.1 Å)