3KW4

Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug ticlopidine

Summary for 3KW4

Entry DOI	10.2210/pdb3kw4/pdb
Related	1PO5 1SUO 2BDM 2Q6N 3G5N 3G93
Descriptor	Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, ticlopidine, ... (6 entities in total)
Functional Keywords	p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2, endoplasmic reticulum, heme, iron, membrane, metal-binding, microsome
Biological source	Oryctolagus cuniculus (rabbit)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
Total number of polymer chains	1
Total formula weight	57522.09
Authors	Gay, S.C.,Maekawa, K.,Roberts, A.G.,Hong, W.-X.,Zhang, Q.,Stout, C.D.,Halpert, J.R. (deposition date: 2009-11-30, release date: 2010-09-15, Last modification date: 2023-09-06)
Primary citation	Gay, S.C.,Roberts, A.G.,Maekawa, K.,Talakad, J.C.,Hong, W.X.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel. Biochemistry, 49:8709-8720, 2010 Cited by PubMed: 20815363 DOI: 10.1021/bi100914z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.67 Å)

Structure validation