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3KCG

Crystal structure of the antithrombin-factor IXa-pentasaccharide complex

Summary for 3KCG
Entry DOI10.2210/pdb3kcg/pdb
Related PRD IDPRD_900031
DescriptorCoagulation factor IXa light chain, Coagulation factor IXa heavy chain, Antithrombin-III, ... (9 entities in total)
Functional Keywordsmichaelis complex, blood coagulation, calcium, disulfide bond, egf-like domain, glycoprotein, hemophilia, hydrolase, pharmaceutical, protease, secreted, serine protease, sulfation, zymogen, heparin-binding, protease inhibitor, serine protease inhibitor, thrombophilia, hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Total number of polymer chains3
Total formula weight84989.27
Authors
Huntington, J.A.,Johnson, D.J.D. (deposition date: 2009-10-21, release date: 2010-02-02, Last modification date: 2023-11-01)
Primary citationJohnson, D.J.,Langdown, J.,Huntington, J.A.
Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex.
Proc.Natl.Acad.Sci.USA, 107:645-650, 2010
Cited by
PubMed: 20080729
DOI: 10.1073/pnas.0910144107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

数据于2024-03-27公开中

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