3K54
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggests a mechanism of activation for TEC family kinases.
3K54 の概要
エントリーDOI | 10.2210/pdb3k54/pdb |
分子名称 | Tyrosine-protein kinase BTK, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE (3 entities in total) |
機能のキーワード | bruton's tyrosine kinase, btk, dasatinib, atp-binding, disease mutation, kinase, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, transferase, tyrosine-protein kinase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm (By similarity): Q06187 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 33134.42 |
構造登録者 | Marcotte, D.J.,Liu, Y.-T.,Arduini, R.M.,Hession, C.A.,Miatkowski, K.,Wildes, C.P.,Cullen, P.F.,Hopkins, B.T.,Mertsching, E.,Jenkins, T.J.,Romanowski, M.J.,Baker, D.P.,Silvian, L.F. (登録日: 2009-10-06, 公開日: 2010-01-19, 最終更新日: 2023-09-06) |
主引用文献 | Marcotte, D.J.,Liu, Y.T.,Arduini, R.M.,Hession, C.A.,Miatkowski, K.,Wildes, C.P.,Cullen, P.F.,Hong, V.,Hopkins, B.T.,Mertsching, E.,Jenkins, T.J.,Romanowski, M.J.,Baker, D.P.,Silvian, L.F. Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases. Protein Sci., 19:429-439, 2010 Cited by PubMed: 20052711DOI: 10.1002/pro.321 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.94 Å) |
構造検証レポート
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