3K3O

Crystal structure of the catalytic core domain of human PHF8 complexed with alpha-ketoglutarate

Summary for 3K3O

• Entry DOI: 10.2210/pdb3k3o/pdb
• Related: 3K3N
• Descriptor: PHD finger protein 8, 2-OXOGLUTARIC ACID, FE (II) ION, ... (4 entities in total)
• Functional Keywords: phf8 (phd finger protein 8), histone demethylase, chromatin modification, methylated h3k9, mental retardation, metal-binding, phosphoprotein, zinc-finger, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43481.29

Authors

Yu, L.,Wang, Y.,Huang, S.,Wang, J.,Deng, Z.,Wu, W.,Gong, W.,Chen, Z. (deposition date: 2009-10-03, release date: 2010-01-19, Last modification date: 2023-11-01)

• Primary citation: Yu, L.,Wang, Y.,Huang, S.,Wang, J.,Deng, Z.,Zhang, Q.,Wu, W.,Zhang, X.,Liu, Z.,Gong, W.,Chen, Z.; Structural insights into a novel histone demethylase PHF8; Cell Res., 20:166-173, 2010; PubMed: 20101266; DOI: 10.1038/cr.2010.8

Experimental method

X-RAY DIFFRACTION (2.1 Å)