3K3B

Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline

3K3B の概要

• エントリーDOI: 10.2210/pdb3k3b/pdb
• 分子名称: Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (8 entities in total)
• 機能のキーワード: protein-ligand complex, atp-binding, cell cycle, cell division, microtubule, mitosis, motor protein, nucleotide-binding, phosphoprotein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P52732
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83920.53

構造登録者

Bussiere, D.E.,Bellamacina, C.,Le, V. (登録日: 2009-10-02, 公開日: 2009-12-15, 最終更新日: 2024-02-21)

• 主引用文献: Barsanti, P.A.,Wang, W.,Ni, Z.J.,Duhl, D.,Brammeier, N.,Martin, E.,Bussiere, D.,Walter, A.O.; The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.; Bioorg.Med.Chem.Lett., 20:157-160, 2010; PubMed: 19945875; DOI: 10.1016/j.bmcl.2009.11.012

実験手法

X-RAY DIFFRACTION (2.4 Å)