3JZI

Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series

Summary for 3JZI

Entry DOI	10.2210/pdb3jzi/pdb
Related	3JZF
Descriptor	Biotin carboxylase, 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide (3 entities in total)
Functional Keywords	biotin carboxylase; accc; acetyl coenzyme-a carboxylase; accase;, atp-binding, biotin, fatty acid biosynthesis, ligase, lipid synthesis, nucleotide-binding
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	107898.03
Authors	Cheng, C.,Shipps, G.W.,Yang, Z.,Sun, B.,Kawahata, N.,Soucy, K.,Soriano, A.,Orth, P.,Xiao, L.,Mann, P.,Black, T. (deposition date: 2009-09-23, release date: 2009-11-03, Last modification date: 2023-09-06)
Primary citation	Cheng, C.C.,Shipps, G.W.,Yang, Z.,Sun, B.,Kawahata, N.,Soucy, K.A.,Soriano, A.,Orth, P.,Xiao, L.,Mann, P.,Black, T. Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19:6507-6514, 2009 Cited by PubMed: 19875284 DOI: 10.1016/j.bmcl.2009.10.057 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.31 Å)

Structure validation