3JSD

Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus

Summary for 3JSD

• Entry DOI: 10.2210/pdb3jsd/pdb
• Related: 1TRZ
• Descriptor: Insulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total)
• Functional Keywords: diabetes mellitus, insulin's biosynthesis, proinsulin, insulin hexamer, carbohydrate metabolism, cleavage on pair of basic residues, disease mutation, disulfide bond, glucose metabolism, hormone, secreted
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 4
• Total formula weight: 11959.19

Authors

Weiss, M.A.,Wan, Z.L.,Dodson, E.J.,Liu, M.,Xu, B.,Hua, Q.X.,Turkenburg, M.,Whittingham, J.,Nakagawa, S.H.,Huang, K.,Hu, S.Q.,Jia, W.H.,Wang, S.H.,Brange, J.,Whittaker, J.,Arvan, P.,Katsoyannis, P.G.,Dodson, G.G. (deposition date: 2009-09-10, release date: 2010-09-15, Last modification date: 2023-09-06)

• Primary citation: Weiss, M.A.,Wan, Z.L.,Dodson, E.J.,Liu, M.,Xu, B.,Hua, Q.X.,Turkenburg, M.,Whittingham, J.,Nakagawa, S.H.,Huang, K.,Hu, S.Q.,Jia, W.H.,Wang, S.H.,Brange, J.,Whittaker, J.,Arvan, P.,Katsoyannis, P.G.,Dodson, G.G.; Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus; To be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)