3IL6

Structure of E. faecalis FabH in complex with 2-({4-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-3-phenoxybenzoyl}amino)benzoic acid

Summary for 3IL6

Entry DOI	10.2210/pdb3il6/pdb
Related	3IL3 3IL4 3IL5 3IL7 3IL9
Descriptor	3-oxoacyl-[acyl-carrier-protein] synthase 3, 2-[({4-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-3-phenoxyphenyl}carbonyl)amino]benzoic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	fabh, fatty acid biosynthesis, antibiotic, acyltransferase, cytoplasm, lipid synthesis, multifunctional enzyme, transferase
Biological source	Enterococcus faecalis
Cellular location	Cytoplasm (Probable): Q820T1
Total number of polymer chains	1
Total formula weight	36206.77
Authors	Gajiwala, K.S.,Margosiak, S.,Lu, J.,Cortez, J.,Su, Y.,Nie, Z.,Appelt, K. (deposition date: 2009-08-06, release date: 2009-08-25, Last modification date: 2023-09-06)
Primary citation	Gajiwala, K.S.,Margosiak, S.,Lu, J.,Cortez, J.,Su, Y.,Nie, Z.,Appelt, K. Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme. Febs Lett., 583:2939-2946, 2009 Cited by PubMed: 19665020 DOI: 10.1016/j.febslet.2009.08.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation