3I9O

Crystal structure of ADP ribosyl cyclase complexed with ribo-2'F-ADP ribose

Summary for 3I9O

Entry DOI	10.2210/pdb3i9o/pdb
Descriptor	ADP-ribosyl cyclase, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4S)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (2 entities in total)
Functional Keywords	homodimer, enzyme-reaction-intermediate complex, adp-ribosyl cyclase, disulfide bond, fertilization, hydrolase, nad
Biological source	Aplysia californica (California sea hare)
Cellular location	Cytoplasmic vesicle: P29241
Total number of polymer chains	2
Total formula weight	60250.50
Authors	Graeff, R.,Liu, Q.,Kriksunov, I.A.,Kotaka, M.,Oppenheimer, N.,Hao, Q.,Lee, H.C. (deposition date: 2009-07-12, release date: 2009-07-28, Last modification date: 2023-11-01)
Primary citation	Graeff, R.,Liu, Q.,Kriksunov, I.A.,Kotaka, M.,Oppenheimer, N.,Hao, Q.,Lee, H.C. Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38 J.Biol.Chem., 284:27629-27636, 2009 Cited by PubMed: 19640843 DOI: 10.1074/jbc.M109.030965 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation