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3HY9

Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound

Summary for 3HY9
Entry DOI10.2210/pdb3hy9/pdb
Related3B8Z 3HY7 3HYG
DescriptorCatalytic Domain of ADAMTS-5, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsalpha/beta structure, central five stranded beta-sheet, hydrolase
Biological sourceHomo sapiens
Cellular locationSecreted, extracellular space, extracellular matrix : Q9UNA0
Total number of polymer chains2
Total formula weight50123.58
Authors
Shieh, H.-S.,Williams, J.M.,Caspers, N.,Mathis, K.J.,Tortorella, M.D.,Tomasselli, A. (deposition date: 2009-06-22, release date: 2009-07-07, Last modification date: 2023-09-06)
Primary citationTortorella, M.D.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Munie, G.,Williams, J.M.,Caspers, N.,Wittwer, A.J.,Malfait, A.M.,Shieh, H.S.
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
J.Biol.Chem., 284:24185-24191, 2009
Cited by
PubMed: 19586907
DOI: 10.1074/jbc.M109.029116
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.02 Å)
Structure validation

217705

數據於2024-03-27公開中

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