3HVO

Structure of the genotype 2B HCV polymerase bound to a NNI

Summary for 3HVO

• Entry DOI: 10.2210/pdb3hvo/pdb
• Related: 2WHO 3GSZ
• Descriptor: Genome polyprotein, 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione (3 entities in total)
• Functional Keywords: viral polymerase, atp-binding, hydrolase, metal-binding, multifunctional enzyme, nucleotide-binding, nucleotidyltransferase, rna replication, rna-binding, rna-directed rna polymerase, transferase
• Biological source: Hepatitis C virus isolate HC-J8 (HCV)
• Total number of polymer chains: 2
• Total formula weight: 126362.13

Authors

Rydberg, E.H.,Carfi, A. (deposition date: 2009-06-16, release date: 2009-08-04, Last modification date: 2023-11-01)

• Primary citation: Ontoria, J.M.,Rydberg, E.H.,Di-Marco, S.,Tomei, L.,Antenni, B.,Melancona, S.,Martin-Hernando, J.I.,Gennari, N.,Koch, U.,Narjes, F.,Rowley, M.,Summa, V.,Carroll, S.S.,Olsen, D.B.,De-Francesco, R.,Altamura, S.,Migliaccio, G.,Carfi, A.; Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)