3HPN

Ligand recognition by A-class EPH receptors: crystal structures of the EPHA2 ligand-binding domain and the EPHA2/EPHRIN-A1 complex

Summary for 3HPN

• Entry DOI: 10.2210/pdb3hpn/pdb
• Descriptor: Ephrin type-A receptor 2 (2 entities in total)
• Functional Keywords: eph receptor tyrosine kinase, ephrin, atp-binding, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P29317
• Total number of polymer chains: 6
• Total formula weight: 119481.55

Authors

Himanen, J.P.,Goldgur, Y.,Miao, H.,Myshkin, E.,Guo, H.,Buck, M.,Nguyen, M.,Rajashankar, K.R.,Wang, B.,Nikolov, D.B. (deposition date: 2009-06-04, release date: 2009-06-30, Last modification date: 2023-09-06)

• Primary citation: Himanen, J.P.,Goldgur, Y.,Miao, H.,Myshkin, E.,Guo, H.,Buck, M.,Nguyen, M.,Rajashankar, K.R.,Wang, B.,Nikolov, D.B.; Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.; Embo Rep., 10:722-728, 2009; PubMed: 19525919; DOI: 10.1038/embor.2009.91

Experimental method

X-RAY DIFFRACTION (2.52 Å)