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3HHM

Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin

Summary for 3HHM
Entry DOI10.2210/pdb3hhm/pdb
Related3HIZ
DescriptorPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, niSH2 p85alpha, (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE, ... (4 entities in total)
Functional Keywordsp110, p85, pi3kca, pi3k, pik3r1, phosphatidilynositol 3, 4, 5-triphosphate, wortmannin, h1047r, atp-binding, disease mutation, kinase, nucleotide-binding, oncogene, polymorphism, transferase, transferase-oncoprotein complex, transferase/oncoprotein
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight171985.01
Authors
Amzel, L.M.,Vogelstein, B.,Gabelli, S.B.,Mandelker, D. (deposition date: 2009-05-15, release date: 2009-09-29, Last modification date: 2023-09-06)
Primary citationMandelker, D.,Gabelli, S.B.,Schmidt-Kittler, O.,Zhu, J.,Cheong, I.,Huang, C.H.,Kinzler, K.W.,Vogelstein, B.,Amzel, L.M.
A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane.
Proc.Natl.Acad.Sci.USA, 106:16996-17001, 2009
Cited by
PubMed: 19805105
DOI: 10.1073/pnas.0908444106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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