3H65

The Crystal Structure of C176A Mutated [Fe]-Hydrogenase (Hmd) Holoenzyme in Complex with Methylenetetrahydromethanopterin

3H65 の概要

• エントリーDOI: 10.2210/pdb3h65/pdb
• 関連するPDBエントリー: 2B0J 3F46 3F47
• 分子名称: 5,10-methenyltetrahydromethanopterin hydrogenase, 5'-O-[(S)-hydroxy{[2-hydroxy-3,5-dimethyl-6-(2-oxoethyl)pyridin-4-yl]oxy}phosphoryl]guanosine, FE (II) ION, ... (7 entities in total)
• 機能のキーワード: rossmann fold, helix bundle, complex with iron guanylyl pyridinol cofactor, c176a mutant, complex with methylenetetrahydromethanopterin, methanogenesis, one-carbon metabolism, oxidoreductase
• 由来する生物種: Methanocaldococcus jannaschii (Methanococcus jannaschii)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40288.21

構造登録者

Hiromoto, T.,Warkentin, E.,Shima, S.,Ermler, U. (登録日: 2009-04-23, 公開日: 2009-09-01, 最終更新日: 2023-11-01)

• 主引用文献: Hiromoto, T.,Warkentin, E.,Moll, J.,Ermler, U.,Shima, S.; The crystal structure of an [Fe]-hydrogenase-substrate complex reveals the framework for H2 activation.; Angew.Chem.Int.Ed.Engl., 48:6457-6460, 2009; PubMed: 19623593; DOI: 10.1002/anie.200902695

実験手法

X-RAY DIFFRACTION (2.15 Å)