3H52

Crystal structure of the antagonist form of human glucocorticoid receptor

Summary for 3H52

• Entry DOI: 10.2210/pdb3h52/pdb
• Descriptor: Glucocorticoid receptor, Nuclear receptor corepressor 1, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, ... (5 entities in total)
• Functional Keywords: protein-ligand complex, nuclear receptor, peptide complex, hormone receptor 3, hormone receptor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm. Isoform Beta: Nucleus: P04150; Nucleus (By similarity): O75376
• Total number of polymer chains: 6
• Total formula weight: 123175.56

Authors

Schoch, G.A.,Benz, J.,D'Arcy, B.,Stihle, M.,Burger, D.,Thoma, R.,Ruf, A. (deposition date: 2009-04-21, release date: 2009-12-01, Last modification date: 2023-11-01)

• Primary citation: Schoch, G.A.,D'Arcy, B.,Stihle, M.,Burger, D.,Bar, D.,Benz, J.,Thoma, R.,Ruf, A.; Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations; J.Mol.Biol., 395:568-577, 2010; PubMed: 19913032; DOI: 10.1016/j.jmb.2009.11.011

Experimental method

X-RAY DIFFRACTION (2.8 Å)