3H3B

Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain

3H3B の概要

分子名称Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21 (3 entities in total)
機能のキーワードimmunoglobulin, beta-helix, protein-protein complex, atp-binding, disulfide bond, kinase, nucleotide-binding, receptor, transferase, transmembrane, tyrosine-protein kinase, immune system
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm P04626
ポリマー鎖数4
分子量合計98458.05
構造登録者
Zhou, H.,Liu, Y.,Niu, L.,Zhu, J.,Teng, M. (登録日: 2009-04-16, 公開日: 2010-04-28, 最終更新日: 2011-09-28)
主引用文献
Zhou, H.,Zha, Z.,Liu, Y.,Zhang, H.,Zhu, J.,Hu, S.,Shen, G.,Cheng, L.,Niu, L.,Greene, M.I.,Teng, M.,Liu, J.
Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21.
J.Biol.Chem., 286:31676-31683, 2011
PubMed: 21680730 (主引用文献が同じPDBエントリー)
DOI: 10.1074/jbc.M111.235184
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.45 Å)
?

構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.254404.4%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード