3H3B

Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain

3H3B の概要

• エントリーDOI: 10.2210/pdb3h3b/pdb
• 分子名称: Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21 (3 entities in total)
• 機能のキーワード: immunoglobulin, beta-helix, protein-protein complex, atp-binding, disulfide bond, kinase, nucleotide-binding, receptor, transferase, transmembrane, tyrosine-protein kinase, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 98458.05

構造登録者

Zhou, H.,Liu, Y.,Niu, L.,Zhu, J.,Teng, M. (登録日: 2009-04-16, 公開日: 2010-04-28, 最終更新日: 2023-11-01)

• 主引用文献: Zhou, H.,Zha, Z.,Liu, Y.,Zhang, H.,Zhu, J.,Hu, S.,Shen, G.,Cheng, L.,Niu, L.,Greene, M.I.,Teng, M.,Liu, J.; Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21.; J.Biol.Chem., 286:31676-31683, 2011; PubMed: 21680730; DOI: 10.1074/jbc.M111.235184

実験手法

X-RAY DIFFRACTION (2.45 Å)