3GQO

Crystal structure of macro domain of Venezuelan Equine Encephalitis virus in complex with ADP-ribose

Summary for 3GQO

• Entry DOI: 10.2210/pdb3gqo/pdb
• Related: 3GPG 3GPO 3GPQ 3GQE
• Descriptor: Non-structural protein 3, ADENOSINE-5-DIPHOSPHORIBOSE (3 entities in total)
• Functional Keywords: macro domain, x domain, venezuelan equine encephalitis virus, alphavirus, virus, adp-ribose, vizier, viral enzymes involved in replication, viral protein
• Biological source: Venezuelan equine encephalitis virus
• Cellular location: Non-structural polyprotein: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . mRNA-capping enzyme nsP1: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Protease nsP2: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase nsP4: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side : P36328
• Total number of polymer chains: 4
• Total formula weight: 75696.75

Authors

Malet, H.,Jamal, S.,Coutard, B.,Ferron, F.,Canard, B. (deposition date: 2009-03-24, release date: 2009-07-21, Last modification date: 2023-09-06)

• Primary citation: Malet, H.,Coutard, B.,Jamal, S.,Dutartre, H.,Papageorgiou, N.,Neuvonen, M.,Ahola, T.,Forrester, N.,Gould, E.A.,Lafitte, D.,Ferron, F.,Lescar, J.,Gorbalenya, A.E.,de Lamballerie, X.,Canard, B.; The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket; J.Virol., 83:6534-6545, 2009; PubMed: 19386706; DOI: 10.1128/JVI.00189-09

Experimental method

X-RAY DIFFRACTION (2.6 Å)