3G8I

Aleglitazar, a new, potent, and balanced PPAR alpha/gamma agonist for the treatment of type II diabetes

3G8I の概要

• エントリーDOI: 10.2210/pdb3g8i/pdb
• 関連するPDBエントリー: 3G9E
• 分子名称: Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid, ... (4 entities in total)
• 機能のキーワード: nuclear hormone receptor, transcription factor, diabetes, activator, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, proto-oncogene, transferase, ubl conjugation, transcription-transferase complex, transcription/transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: Q07869; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32670.12

構造登録者

Benz, J.,Bernardeau, A.,Binggeli, A.,Blum, D.,Boehringer, M.,Grether, U.,Hilpert, H.,Kuhn, B.,Maerki, H.P.,Meyer, M.,Puentener, K.,Raab, S.,Ruf, A.,Schlatter, D.,Gsell, B.,Stihle, M.,Mohr, P. (登録日: 2009-02-12, 公開日: 2009-06-02, 最終更新日: 2023-11-01)

• 主引用文献: Benardeau, A.,Benz, J.,Binggeli, A.,Blum, D.,Boehringer, M.,Grether, U.,Hilpert, H.,Kuhn, B.,Marki, H.P.,Meyer, M.,Puntener, K.,Raab, S.,Ruf, A.,Schlatter, D.,Mohr, P.; Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.; Bioorg.Med.Chem.Lett., 19:2468-2473, 2009; PubMed: 19349176; DOI: 10.1016/j.bmcl.2009.03.036

実験手法

X-RAY DIFFRACTION (2.2 Å)