3G77
Bacterial cytosine deaminase V152A/F316C/D317G mutant
Summary for 3G77
| Entry DOI | 10.2210/pdb3g77/pdb |
| Related | 1K6W 1R9Y 1R9Z 1RA0 1RAK 1RB7 |
| Descriptor | Cytosine deaminase, FE (III) ION (3 entities in total) |
| Functional Keywords | cytosine deaminase, protein engineering, cytosine metabolism, hydrolase, iron, metal-binding |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 47124.04 |
| Authors | Stoddard, B.,Zhao, L. (deposition date: 2009-02-09, release date: 2009-09-22, Last modification date: 2024-02-21) |
| Primary citation | Fuchita, M.,Ardiani, A.,Zhao, L.,Serve, K.,Stoddard, B.L.,Black, M.E. Bacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo. Cancer Res., 69:4791-4799, 2009 Cited by PubMed: 19487291DOI: 10.1158/0008-5472.CAN-09-0615 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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