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3G5N

Triple ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole

Summary for 3G5N
Entry DOI10.2210/pdb3g5n/pdb
Related1PO5 1SUO 2BDM 2Q6N
DescriptorCytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 1-(biphenyl-4-ylmethyl)-1H-imidazole, ... (5 entities in total)
Functional Keywordsp450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2, endoplasmic reticulum, heme, iron, membrane, metal-binding, microsome, phosphoprotein, polymorphism
Biological sourceOryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Cellular locationEndoplasmic reticulum membrane; Peripheral membrane protein: P00178
Total number of polymer chains4
Total formula weight223932.12
Authors
Gay, S.C.,Sun, L.,Maekawa, K.,Halpert, J.R.,Stout, C.D. (deposition date: 2009-02-05, release date: 2009-05-12, Last modification date: 2023-09-06)
Primary citationGay, S.C.,Sun, L.,Maekawa, K.,Halpert, J.R.,Stout, C.D.
Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Biochemistry, 48:4762-4771, 2009
Cited by
PubMed: 19397311
DOI: 10.1021/bi9003765
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

數據於2024-03-27公開中

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