3G04

Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody

3G04 の概要

• エントリーDOI: 10.2210/pdb3g04/pdb
• 関連するPDBエントリー: 1XWD
• 分子名称: HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN, HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN, Thyrotropin receptor, ... (6 entities in total)
• 機能のキーワード: tsh receptor, gpcr, thyroid, graves' disease, autoimmunity, receptor-autoantibody complex, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 76128.97

構造登録者

Sanders, J.,Chirgadze, D.Y.,Sanders, P.,Baker, S.,Sullivan, A.,Bhardwaja, A.,Bolton, J.,Reeve, M.,Nakatake, N.,Evans, M.,Richards, T.,Powell, M.,Miguel, R.N.,Blundell, T.L.,Furmaniak, J.,Smith, B.R. (登録日: 2009-01-27, 公開日: 2009-08-04, 最終更新日: 2023-11-01)

• 主引用文献: Sanders, J.,Chirgadze, D.Y.,Sanders, P.,Baker, S.,Sullivan, A.,Bhardwaja, A.,Bolton, J.,Reeve, M.,Nakatake, N.,Evans, M.,Richards, T.,Powell, M.,Miguel, R.N.,Blundell, T.L.,Furmaniak, J.,Smith, B.R.; Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody; Thyroid, 17:395-410, 2007; PubMed: 17542669; DOI: 10.1089/thy.2007.0034

実験手法

X-RAY DIFFRACTION (2.55 Å)