3FZR
Crystal structure of PYK2 complexed with PF-431396
Summary for 3FZR
Entry DOI | 10.2210/pdb3fzr/pdb |
Related | 3FZO 3FZP 3FZS 3FZT |
Descriptor | Protein tyrosine kinase 2 beta, N-methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | pyk2, kinase, dfg, alternative splicing, atp-binding, cell membrane, cytoplasm, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q14289 |
Total number of polymer chains | 1 |
Total formula weight | 32791.79 |
Authors | |
Primary citation | Han, S.,Mistry, A.,Chang, J.S.,Cunningham, D.,Griffor, M.,Bonnette, P.C.,Wang, H.,Chrunyk, B.A.,Aspnes, G.E.,Walker, D.P.,Brosius, A.D.,Buckbinder, L. Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem., 284:13193-13201, 2009 Cited by PubMed: 19244237DOI: 10.1074/jbc.M809038200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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