3FVH

Polo-like kinase 1 Polo box domain in complex with Ac-LHSpTA-NH2 peptide

3FVH の概要

• エントリーDOI: 10.2210/pdb3fvh/pdb
• 分子名称: Serine/threonine-protein kinase PLK1, Acetyl-Leu-His-Ser-phosphoThr-Ala-NH2 peptide (3 entities in total)
• 機能のキーワード: polo like kinase 1, polo box domain, phosphopeptide binding domain, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, peptide binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: P53350
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27917.76

構造登録者

Lim, D.C.,Yaffe, M.B. (登録日: 2009-01-15, 公開日: 2009-08-04, 最終更新日: 2023-09-06)

• 主引用文献: Yun, S.M.,Moulaei, T.,Lim, D.,Bang, J.K.,Park, J.E.,Shenoy, S.R.,Liu, F.,Kang, Y.H.,Liao, C.,Soung, N.K.,Lee, S.,Yoon, D.Y.,Lim, Y.,Lee, D.H.,Otaka, A.,Appella, E.,McMahon, J.B.,Nicklaus, M.C.,Burke, T.R.,Yaffe, M.B.,Wlodawer, A.,Lee, K.S.; Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1; Nat.Struct.Mol.Biol., 16:876-882, 2009; PubMed: 19597481; DOI: 10.1038/nsmb.1628

実験手法

X-RAY DIFFRACTION (1.58 Å)