6Q0C

MutY adenine glycosylase bound to DNA containing a transition state analog (1N) paired with undamaged dG

Replaces:  3FSP

Summary for 6Q0C

• Entry DOI: 10.2210/pdb6q0c/pdb
• Related: 6U7T
• Descriptor: A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*GP*TP*GP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*CP*AP*(NR1)P*GP*TP*CP*T)-3'), ... (7 entities in total)
• Functional Keywords: protein-dna complex, dna repair, transition state analog, hydrolase-dna complex, hydrolase/dna
• Biological source: Geobacillus stearothermophilus; More
• Total number of polymer chains: 3
• Total formula weight: 48862.76

Authors

O'Shea Murray, V.L.,Russelburg, L.P.,Horvath, M.P.,David, S.S. (deposition date: 2019-08-01, release date: 2019-08-28, Last modification date: 2023-10-11)

• Primary citation: Russelburg, L.P.,O'Shea Murray, V.L.,Demir, M.,Knutsen, K.R.,Sehgal, S.L.,Cao, S.,David, S.S.,Horvath, M.P.; Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY.; Acs Chem.Biol., 15:93-102, 2020; PubMed: 31829624; DOI: 10.1021/acschembio.9b00639

Experimental method

X-RAY DIFFRACTION (2 Å)