3FGT

Two chain form of the 66.3 kDa protein from mouse lacking the linker peptide

Summary for 3FGT

• Entry DOI: 10.2210/pdb3fgt/pdb
• Related: 3FBX 3FGR 3FGW
• Descriptor: Putative phospholipase B-like 2 28 kDa form, Putative phospholipase B-like 2 40 kDa form, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: alpha beta, glycosylated, disulphide bonds, n-terminal nucleophile hydrolase fold, two chain form, glycoprotein, hydrolase, lipid degradation, lysosome
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 2
• Total formula weight: 65477.61

Authors

Lakomek, K.,Dickmanns, A.,Ficner, R. (deposition date: 2008-12-08, release date: 2009-09-15, Last modification date: 2023-11-22)

Primary citation

Lakomek, K.,Dickmanns, A.,Kettwig, M.,Urlaub, H.,Ficner, R.,Luebke, T.
Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography
Bmc Struct.Biol., 9:56-56, 2009

PubMed Abstract: The lysosomal 66.3 kDa protein from mouse is a soluble, mannose 6-phosphate containing protein of so far unknown function. It is synthesized as a glycosylated 75 kDa precursor that undergoes limited proteolysis leading to a 28 kDa N- and a 40 kDa C-terminal fragment.

PubMed: 19706171
DOI: 10.1186/1472-6807-9-56

Experimental method

X-RAY DIFFRACTION (2.4 Å)