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3ETA

Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor

Summary for 3ETA
Entry DOI10.2210/pdb3eta/pdb
Descriptorinsulin receptor, kinase domain, 1-(3-{5-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea (3 entities in total)
Functional Keywordsatp-binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase, signaling protein
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight73363.77
Authors
Patnaik, S.,Stevens, K.,Gerding, R.,Deanda, F.,Shotwell, B.,Tang, J.,Hamajima, T.,Nakamura, H.,Leesnitzer, A.,Hassell, A.,Shewchuk, L.,Kumar, R.,Lei, H.,Chamberlain, S. (deposition date: 2008-10-07, release date: 2009-05-26, Last modification date: 2023-09-06)
Primary citationPatnaik, S.,Stevens, K.L.,Gerding, R.,Deanda, F.,Shotwell, J.B.,Tang, J.,Hamajima, T.,Nakamura, H.,Leesnitzer, M.A.,Hassell, A.M.,Shewchuck, L.M.,Kumar, R.,Lei, H.,Chamberlain, S.D.
Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase.
Bioorg.Med.Chem.Lett., 19:3136-3140, 2009
Cited by
PubMed: 19394223
DOI: 10.1016/j.bmcl.2008.12.110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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