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3EP6

Human AdoMetDC D174N mutant complexed with S-Adenosylmethionine methyl ester and no putrescine bound

Summary for 3EP6
Entry DOI10.2210/pdb3ep6/pdb
Related1I72 1I79 1I7B 1I7C 1I7M 1JEN 3EP3 3EP4 3EP5 3EP7 3EP8 3EP9 3EPA 3EPB
DescriptorS-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, PYRUVIC ACID, ... (5 entities in total)
Functional Keywordsadometdc with mutation in putrescine binding site, decarboxylase, lyase, pyruvate, s-adenosyl-l-methionine, spermidine biosynthesis, zymogen
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight38084.35
Authors
Bale, S.,Lopez, M.M.,Makhatadze, G.I.,Fang, Q.,Pegg, A.E.,Ealick, S.E. (deposition date: 2008-09-29, release date: 2008-12-23, Last modification date: 2023-11-15)
Primary citationBale, S.,Lopez, M.M.,Makhatadze, G.I.,Fang, Q.,Pegg, A.E.,Ealick, S.E.
Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase.
Biochemistry, 47:13404-13417, 2008
Cited by
PubMed: 19053272
DOI: 10.1021/bi801732m
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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