3EBO

Glycogen Phosphorylase b/Chrysin complex

Summary for 3EBO

Entry DOI	10.2210/pdb3ebo/pdb
Related	1c8k 1e1y 3EBP
Descriptor	Glycogen phosphorylase, muscle form, chrysin (3 entities in total)
Functional Keywords	glycogen phosphorylase, catalytic site, rational inhibitor design, glycogenolysis, diabetes type 2, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Total number of polymer chains	1
Total formula weight	97773.56
Authors	Oikonomakos, N.G.,Zographos, S.E.,Leonidas, D.D.,Hayes, J.M.,Tiraidis, C.,Alexacou, K.-M. (deposition date: 2008-08-28, release date: 2009-09-01, Last modification date: 2023-11-15)
Primary citation	Tsitsanou, K.E.,Hayes, J.M.,Keramioti, M.,Mamais, M.,Oikonomakos, N.G.,Kato, A.,Leonidas, D.D.,Zographos, S.E. Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: Comparison of chrysin and flavopiridol Food Chem.Toxicol., 61:14-27, 2013 Cited by PubMed: 23279842 DOI: 10.1016/j.fct.2012.12.030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation