3DY4

Crystal structure of yeast 20S proteasome in complex with spirolactacystin

Summary for 3DY4

Entry DOI	10.2210/pdb3dy4/pdb
Related	1RYP 3DY3
Descriptor	Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
Functional Keywords	proteasome, inhibitor, protein degradation, ubiquitin-proteasome-pathway, hydrolase, nucleus, protease, threonine protease, phosphoprotein, zymogen
Biological source	Saccharomyces cerevisiae (Baker's yeast) More
Cellular location	Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
Total number of polymer chains	28
Total formula weight	705067.22
Authors	Groll, M.,Balskus, E.,Jacobsen, E. (deposition date: 2008-07-25, release date: 2008-11-04, Last modification date: 2024-03-13)
Primary citation	Groll, M.,Balskus, E.P.,Jacobsen, E.N. Structural analysis of spiro beta-lactone proteasome inhibitors. J.Am.Chem.Soc., 130:14981-14983, 2008 Cited by PubMed: 18928262 DOI: 10.1021/ja806059t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation