3DSE

A potent peptidomimetic inhibitor of botulinum neurotoxin serotype A has a very different conformation than SNAP-25 substrate

Summary for 3DSE

Entry DOI	10.2210/pdb3dse/pdb
Related	1XTF 2ISG 3DS9 3DSE
Descriptor	Botulinum neurotoxin type A, ZINC ION, NICKEL (II) ION, ... (4 entities in total)
Functional Keywords	snare, botulism, inhibition, metalloprotease, neurotransmission, neuromuscular junction, hydrolase, membrane, metal-binding, neurotoxin, pharmaceutical, protease, secreted, toxin, transmembrane, zinc
Biological source	Clostridium botulinum
Cellular location	Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
Total number of polymer chains	1
Total formula weight	47902.09
Authors	Zuniga, J.E.,Fenn, T. (deposition date: 2008-07-11, release date: 2008-09-30, Last modification date: 2024-02-21)
Primary citation	Zuniga, J.E.,Schmidt, J.J.,Fenn, T.,Burnett, J.C.,Arac, D.,Gussio, R.,Stafford, R.G.,Badie, S.S.,Bavari, S.,Brunger, A.T. A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate Structure, 16:1588-1597, 2008 Cited by PubMed: 18940613 DOI: 10.1016/j.str.2008.07.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation