3D4S

Cholesterol bound form of human beta2 adrenergic receptor.

Summary for 3D4S

• Entry DOI: 10.2210/pdb3d4s/pdb
• Related: 2RH1
• Descriptor: Beta-2 adrenergic receptor/T4-lysozyme chimera, (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol, CHOLESTEROL, ... (5 entities in total)
• Functional Keywords: gpcr, membrane protein, lysozyme, fusion, adrenergic, timolol, g-protein coupled receptor, glycoprotein, lipoprotein, palmitate, phosphoprotein, receptor, transducer, transmembrane, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, gpcr network
• Biological source: Homo sapiens; More
• Cellular location: Cell membrane ; Multi- pass membrane protein : P07550
• Total number of polymer chains: 1
• Total formula weight: 58117.27

Authors

Hanson, M.A.,Cherezov, V.,Roth, C.B.,Griffith, M.T.,Jaakola, V.-P.,Chien, E.Y.T.,Velasquez, J.,Kuhn, P.,Stevens, R.C.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D),GPCR Network (GPCR) (deposition date: 2008-05-14, release date: 2008-06-17, Last modification date: 2023-08-30)

• Primary citation: Hanson, M.A.,Cherezov, V.,Griffith, M.T.,Roth, C.B.,Jaakola, V.P.,Chien, E.Y.,Velasquez, J.,Kuhn, P.,Stevens, R.C.; A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.; Structure, 16:897-905, 2008; PubMed: 18547522; DOI: 10.1016/j.str.2008.05.001

Experimental method

X-RAY DIFFRACTION (2.8 Å)