3CY2

Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand II

Summary for 3CY2

• Entry DOI: 10.2210/pdb3cy2/pdb
• Related: 3CXW 3CY3
• Descriptor: Proto-oncogene serine/threonine-protein kinase Pim-1, Isoform 2, Pimtide peptide, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: oncogene, kinase, serine-threonine, pim1, structural genomics consortium, sgc, alternative initiation, atp-binding, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, host-virus interaction, viral immunoevasion, virion, virulence
• Biological source: Homo sapiens; More
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 2
• Total formula weight: 37738.85

Authors

Filippakopoulos, P.,Bullock, A.,Fedorov, O.,Huber, K.,Bracher, F.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-04-25, release date: 2008-07-15, Last modification date: 2023-08-30)

• Primary citation: Huber, K.,Brault, L.,Fedorov, O.,Gasser, C.,Filippakopoulos, P.,Bullock, A.N.,Fabbro, D.,Trappe, J.,Schwaller, J.,Knapp, S.,Bracher, F.; 7,8-Dichloro-1-oxo-beta-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes; J.Med.Chem., 55:403-413, 2012; PubMed: 22136433; DOI: 10.1021/jm201286z

Experimental method

X-RAY DIFFRACTION (2.01 Å)