3CQW

Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor

Summary for 3CQW

Entry DOI	10.2210/pdb3cqw/pdb
Related	3CQU
Descriptor	RAC-alpha serine/threonine-protein kinase, Glycogen synthase kinase-3 beta, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	kinase, apoptosis, atp-binding, carbohydrate metabolism, cytoplasm, glucose metabolism, glycogen biosynthesis, glycogen metabolism, membrane, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, sugar transport, transferase, translation regulation, transport, alternative splicing, wnt signaling pathway
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P31749 P49841
Total number of polymer chains	2
Total formula weight	41060.96
Authors	Pandit, J. (deposition date: 2008-04-03, release date: 2008-05-27, Last modification date: 2021-10-20)
Primary citation	Lippa, B.,Pan, G.,Corbett, M.,Li, C.,Kauffman, G.S.,Pandit, J.,Robinson, S.,Wei, L.,Kozina, E.,Marr, E.S.,Borzillo, G.,Knauth, E.,Barbacci-Tobin, E.G.,Vincent, P.,Troutman, M.,Baker, D.,Rajamohan, F.,Kakar, S.,Clark, T.,Morris, J. Synthesis and structure based optimization of novel Akt inhibitors Bioorg.Med.Chem.Lett., 18:3359-3363, 2008 Cited by PubMed: 18456494 DOI: 10.1016/j.bmcl.2008.04.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation