3CAQ

Crystal structure of 5beta-reductase (AKR1D1) in complex with NADPH

Summary for 3CAQ

Entry DOI	10.2210/pdb3caq/pdb
Related	3CAS 3CAV
Descriptor	3-oxo-5-beta-steroid 4-dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, BETA-MERCAPTOETHANOL, ... (6 entities in total)
Functional Keywords	5b-reductase, 5beta-reductase, 5b-red, akr1d1, akr, aldo-keto reductase, nadp, androstenedione, nadph, 5b-dhp, substrate inhibition, bile acid catabolism, cytoplasm, disease mutation, lipid metabolism, oxidoreductase, steroid metabolism
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P51857
Total number of polymer chains	2
Total formula weight	76925.46
Authors	Faucher, F.,Cantin, L.,Breton, R. (deposition date: 2008-02-20, release date: 2008-12-09, Last modification date: 2024-02-21)
Primary citation	Faucher, F.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R. Crystal Structures of Human Delta4-3-Ketosteroid 5beta-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition (dagger) (,) (double dagger). Biochemistry, 47:13537-13546, 2008 Cited by PubMed: 19075558 DOI: 10.1021/bi801276h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation