3BXS
Crystal Structures Of Highly Constrained Substrate And Hydrolysis Products Bound To HIV-1 Protease. Implications For Catalytic Mechanism
Summary for 3BXS
Entry DOI | 10.2210/pdb3bxs/pdb |
Related | 1B6P |
Descriptor | Protease, SULFATE ION, (9S,12S)-9-(1-methylethyl)-7,10-dioxo-2-oxa-8,11-diazabicyclo[12.2.2]octadeca-1(16),14,17-triene-12-carboxylic acid, ... (4 entities in total) |
Functional Keywords | hiv protease, hivpr, substrate, product, aids, aspartyl protease, capsid maturation, core protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22544.40 |
Authors | Tyndall, J.D.,Pattenden, L.K.,Reid, R.C.,Hu, S.H.,Alewood, D.,Alewood, P.F.,Walsh, T.,Fairlie, D.P.,Martin, J.L. (deposition date: 2008-01-14, release date: 2008-03-25, Last modification date: 2023-11-15) |
Primary citation | Tyndall, J.D.,Pattenden, L.K.,Reid, R.C.,Hu, S.H.,Alewood, D.,Alewood, P.F.,Walsh, T.,Fairlie, D.P.,Martin, J.L. Crystal Structures of Highly Constrained Substrate and Hydrolysis Products Bound to HIV-1 Protease. Implications for the Catalytic Mechanism Biochemistry, 47:3736-3744, 2008 Cited by PubMed: 18311928DOI: 10.1021/bi7023157 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)