3B7V

HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate NLLTQI

Summary for 3B7V

• Entry DOI: 10.2210/pdb3b7v/pdb
• Related: 3B80
• Related PRD ID: PRD_000321
• Descriptor: Protease, peptide, SODIUM ION, ... (6 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus type 1 BH10; More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04587
• Total number of polymer chains: 3
• Total formula weight: 22421.64

Authors

Kovalevsky, A.Y.,Chumanevich, A.A.,Weber, I.T. (deposition date: 2007-10-31, release date: 2007-12-18, Last modification date: 2023-08-30)

• Primary citation: Kovalevsky, A.Y.,Chumanevich, A.A.,Liu, F.,Louis, J.M.,Weber, I.T.; Caught in the Act: The 1.5 A Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate.; Biochemistry, 46:14854-14864, 2007; PubMed: 18052235; DOI: 10.1021/bi700822g

Experimental method

X-RAY DIFFRACTION (1.46 Å)