3B7U

Leukotriene A4 Hydrolase Complexed with KELatorphan

3B7U の概要

• エントリーDOI: 10.2210/pdb3b7u/pdb
• 関連するPDBエントリー: 2R59 3B7R 3B7S 3B7T
• 分子名称: Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ... (7 entities in total)
• 機能のキーワード: transition state, analogue peptide, hydrolysis, alternative splicing, cytoplasm, hydrolase, leukotriene biosynthesis, metal-binding, metalloprotease, multifunctional enzyme, protease, zinc
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 71069.62

構造登録者

Tholander, F.,Haeggstrom, J.,Thunnissen, M.,Muroya, A.,Roques, B.-P.,Fournie-Zaluski, M.-C. (登録日: 2007-10-31, 公開日: 2008-09-16, 最終更新日: 2023-08-30)

• 主引用文献: Tholander, F.,Muroya, A.,Roques, B.P.,Fournie-Zaluski, M.C.,Thunnissen, M.M.,Haeggstrom, J.Z.; Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.; Chem.Biol., 15:920-929, 2008; PubMed: 18804029; DOI: 10.1016/j.chembiol.2008.07.018

実験手法

X-RAY DIFFRACTION (1.9 Å)