3B4V

X-Ray structure of Activin in complex with FSTL3

Summary for 3B4V

Entry DOI	10.2210/pdb3b4v/pdb
Descriptor	Inhibin beta A chain, follistatin-like 3, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	ligand-inhibitor signalling complex, cleavage on pair of basic residues, glycoprotein, growth factor, hormone, secreted, nucleus, proto-oncogene, hormone regulator complex
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	152645.57
Authors	Thompson, T.B. (deposition date: 2007-10-24, release date: 2008-09-02, Last modification date: 2020-07-29)
Primary citation	Stamler, R.,Keutmann, H.T.,Sidis, Y.,Kattamuri, C.,Schneyer, A.,Thompson, T.B. The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. J.Biol.Chem., 283:32831-32838, 2008 Cited by PubMed: 18768470 DOI: 10.1074/jbc.M801266200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation