3AO1

Fragment-based approach to the design of ligands targeting a novel site in HIV-1 integrase

Summary for 3AO1

Entry DOI	10.2210/pdb3ao1/pdb
Related	3AO2 3AO3 3AO4 3AO5 3OVN 3l3u
Descriptor	POL polyprotein, CADMIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	dna integration, aids, integrase, endonuclease, polynucleotidyl transferase, dna binding, viral protein, rnaseh, fragment binding, viral protein-transferase inhibitor complex, viral protein/transferase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	36564.42
Authors	Wielens, J.,Parker, M.W.,Chalmers, D.K.,Scanlon, M.J. (deposition date: 2010-09-17, release date: 2011-03-09, Last modification date: 2023-11-01)
Primary citation	Wielens, J.,Headey, S.J.,Deadman, J.J.,Rhodes, D.I.,Parker, M.W.,Chalmers, D.K.,Scanlon, M.J. Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6:258-261, 2011 Cited by PubMed: 21275048 DOI: 10.1002/cmdc.201000483 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation