3AHA

Crystal structure of the complex between gp41 fragments N36 and C34 mutant N126K/E137Q

Summary for 3AHA

• Entry DOI: 10.2210/pdb3aha/pdb
• Descriptor: Transmembrane protein gp41, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: coiled-coil, viral protein-inhibitor complex, membrane protein
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Cellular location: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: Q70626
• Total number of polymer chains: 6
• Total formula weight: 25684.88

Authors

Izumi, K.,Nakamura, S.,Nakano, H.,Shimura, K.,Sakagami, Y.,Oishi, S.,Uchiyama, S.,Ohkubo, T.,Kobayashi, Y.,Fujii, N.,Matsuoka, M.,Kodama, E.N. (deposition date: 2010-04-22, release date: 2010-05-19, Last modification date: 2023-11-01)

• Primary citation: Izumi, K.,Nakamura, S.,Nakano, H.,Shimura, K.,Sakagami, Y.,Oishi, S.,Uchiyama, S.,Ohkubo, T.,Kobayashi, Y.,Fujii, N.,Matsuoka, M.,Kodama, E.N.; Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino terminal heptad repeat.; Antiviral Res., 2010; PubMed: 20438763; DOI: 10.1016/j.antiviral.2010.04.011

Experimental method

X-RAY DIFFRACTION (1.7 Å)