3UPN

Structure of penicillin-binding protein A from M. tuberculosis: imipenem acyl-enzyme complex

Summary for 3UPN

Entry DOI	10.2210/pdb3upn/pdb
Related	3LO7 3UN7 3UPO 3UPP
Descriptor	Penicillin-binding protein A, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid (3 entities in total)
Functional Keywords	transpeptidase, peptidoglycan, beta-lactam, penicillin-binding protein-antibiotic complex, penicillin-binding protein/antibiotic
Biological source	Mycobacterium tuberculosis
Cellular location	Cell membrane; Single-pass type II membrane protein (Probable): P71586
Total number of polymer chains	2
Total formula weight	97531.71
Authors	Davies, C.,Fedorovich, A. (deposition date: 2011-11-18, release date: 2012-10-24, Last modification date: 2023-09-13)
Primary citation	Fedarovich, A.,Nicholas, R.A.,Davies, C. The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis J.Mol.Biol., 418:316-330, 2012 Cited by PubMed: 22365933 DOI: 10.1016/j.jmb.2012.02.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation