3T04

Crystal structure of monobody 7c12/abl1 sh2 domain complex

Summary for 3T04

Entry DOI	10.2210/pdb3t04/pdb
Descriptor	Tyrosine-protein kinase ABL1, MONOBODY 7C12, GLYCEROL, ... (5 entities in total)
Functional Keywords	engineered binding protein, antibody mimic, protein-protein complex, sh2 domain, atp-binding, phosphoprotein, tyrosine-protein kinase, signaling protein-protein binding complex, signaling protein/protein binding
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
Total number of polymer chains	2
Total formula weight	25465.86
Authors	Wojcik, J.B.,Wyrzucki, A.M.,Koide, S. (deposition date: 2011-07-19, release date: 2011-11-23, Last modification date: 2023-09-13)
Primary citation	Grebien, F.,Hantschel, O.,Wojcik, J.,Kaupe, I.,Kovacic, B.,Wyrzucki, A.M.,Gish, G.D.,Cerny-Reiterer, S.,Koide, A.,Beug, H.,Pawson, T.,Valent, P.,Koide, S.,Superti-Furga, G. Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis. Cell(Cambridge,Mass.), 147:306-319, 2011 Cited by PubMed: 22000011 DOI: 10.1016/j.cell.2011.08.046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation