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3PNH

Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in complex with 6-(((3R,4R)-4-(2-((2-FLUORO-2-(3-FLUOROPHENYL) ETHYL)AMINO)ETHOXY)PYRROLIDIN-3-YL)METHYL)-4-METHYLPYRIDIN-2-AMINE

Summary for 3PNH
Entry DOI10.2210/pdb3pnh/pdb
Related3PNE 3PNF 3PNG
DescriptorNitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (9 entities in total)
Functional Keywordsheme enzyme, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological sourceBos taurus (bovine,cow,domestic cattle,domestic cow)
Cellular locationCell membrane : P29473
Total number of polymer chains2
Total formula weight96848.14
Authors
Delker, S.L.,Li, H.,Poulos, T.L. (deposition date: 2010-11-18, release date: 2011-10-05, Last modification date: 2024-02-21)
Primary citationXue, F.,Kraus, J.M.,Labby, K.J.,Ji, H.,Mataka, J.,Xia, G.,Li, H.,Delker, S.L.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Improved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide Synthase.
J.Med.Chem., 54:6399-6403, 2011
Cited by
PubMed: 21809851
DOI: 10.1021/jm200411j
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.93 Å)
Structure validation

217705

數據於2024-03-27公開中

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