3P5J

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease

Summary for 3P5J

Entry DOI	10.2210/pdb3p5j/pdb
Related	3P56
Descriptor	Ribonuclease H2 subunit A, Ribonuclease H2 subunit B, Ribonuclease H2 subunit C (3 entities in total)
Functional Keywords	rnase h2 fold, triple beta-barrel, nuclease that cleaves rna/dna hybrids, proliferating cell nuclear antigen (pcna) and rna/dna hybrids, nucleus, hydrolase-replication complex, hydrolase/replication
Biological source	Mus musculus (mouse) More
Cellular location	Nucleus (By similarity): Q9CWY8 Q80ZV0 Q9CQ18
Total number of polymer chains	3
Total formula weight	88889.91
Authors	Bubeck, D.,Graham, S.C.,Jones, E.Y. (deposition date: 2010-10-08, release date: 2010-11-17, Last modification date: 2024-02-21)
Primary citation	Reijns, M.A.,Bubeck, D.,Gibson, L.C.,Graham, S.C.,Baillie, G.S.,Jones, E.Y.,Jackson, A.P. The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease. J.Biol.Chem., 286:10530-10539, 2011 Cited by PubMed: 21177854 DOI: 10.1074/jbc.M110.177394 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation