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3NLJ

Structure of neuronal nitric oxide synthase D597N/M336V/Y706A triple mutant heme domain complexed with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy] pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine

Summary for 3NLJ
Entry DOI10.2210/pdb3nlj/pdb
Related3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLU 3NLV 3NLW 3NLX 3NLY 3NLZ 3NM0
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywordsnitric oxide synthase, heme enzyme, substrate inhibitor, oxidoreductase
Biological sourceRattus norvegicus (brown rat,rat,rats)
Total number of polymer chains2
Total formula weight99953.28
Authors
Delker, S.L.,Li, H.,Poulos, T.L. (deposition date: 2010-06-21, release date: 2010-11-03, Last modification date: 2024-02-21)
Primary citationJi, H.,Delker, S.L.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives.
J.Med.Chem., 53:7804-7824, 2010
Cited by
PubMed: 20958055
DOI: 10.1021/jm100947x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

數據於2024-03-27公開中

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