5YRS
X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate
Replaces: 3MIMSummary for 5YRS
Entry DOI | 10.2210/pdb5yrs/pdb |
Related | 1G6L 1LV1 2NPH |
Descriptor | PROTEASE, RT-RH oligopeprtide, ... (4 entities in total) |
Functional Keywords | hiv-1 protease, tetrahedral intermediate, short ionic hydrogen bond, substrate complex, rt-rh, hydrolase |
Biological source | Human immunodeficiency virus 1 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
Total number of polymer chains | 3 |
Total formula weight | 23040.88 |
Authors | Das, A.,Mahale, S.,Prashar, V.,Bihani, S.,Ferrer, J.-L.,Hosur, M.V. (deposition date: 2017-11-10, release date: 2018-03-07, Last modification date: 2023-11-22) |
Primary citation | Das, A.,Mahale, S.,Prashar, V.,Bihani, S.,Ferrer, J.L.,Hosur, M.V. X-ray snapshot of HIV-1 protease in action: observation of tetrahedral intermediate and short ionic hydrogen bond SIHB with catalytic aspartate. J. Am. Chem. Soc., 132:6366-6373, 2010 Cited by PubMed: 20397633DOI: 10.1021/ja100002b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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