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5YRS

X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate

Replaces:  3MIM
Summary for 5YRS
Entry DOI10.2210/pdb5yrs/pdb
Related1G6L 1LV1 2NPH
DescriptorPROTEASE, RT-RH oligopeprtide, ... (4 entities in total)
Functional Keywordshiv-1 protease, tetrahedral intermediate, short ionic hydrogen bond, substrate complex, rt-rh, hydrolase
Biological sourceHuman immunodeficiency virus 1 (HIV-1)
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
Total number of polymer chains3
Total formula weight23040.88
Authors
Das, A.,Mahale, S.,Prashar, V.,Bihani, S.,Ferrer, J.-L.,Hosur, M.V. (deposition date: 2017-11-10, release date: 2018-03-07, Last modification date: 2023-11-22)
Primary citationDas, A.,Mahale, S.,Prashar, V.,Bihani, S.,Ferrer, J.L.,Hosur, M.V.
X-ray snapshot of HIV-1 protease in action: observation of tetrahedral intermediate and short ionic hydrogen bond SIHB with catalytic aspartate.
J. Am. Chem. Soc., 132:6366-6373, 2010
Cited by
PubMed: 20397633
DOI: 10.1021/ja100002b
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.76 Å)
Structure validation

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