3MBY

Ternary complex of DNA Polymerase BETA with template base A and 8oxodGTP in the active site with a dideoxy terminated primer

Summary for 3MBY

• Entry DOI: 10.2210/pdb3mby/pdb
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ... (9 entities in total)
• Functional Keywords: nucleotidyl transferase, dna polymerase, a:(syn)8oxodgtp, a:c transversion, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 48398.68

Authors

Batra, V.K.,Beard, W.A.,Hou, E.W.,Pedersen, L.C.,Prasad, R.,Wilson, S.H. (deposition date: 2010-03-26, release date: 2010-06-09, Last modification date: 2023-09-06)

• Primary citation: Batra, V.K.,Beard, W.A.,Hou, E.W.,Pedersen, L.C.,Prasad, R.,Wilson, S.H.; Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site.; Nat.Struct.Mol.Biol., 17:889-890, 2010; PubMed: 20526335; DOI: 10.1038/nsmb.1852

Experimental method

X-RAY DIFFRACTION (2 Å)