3K2U
Crystal structure of HGFA in complex with the allosteric inhibitory antibody Fab40
Summary for 3K2U
Entry DOI | 10.2210/pdb3k2u/pdb |
Related | 1YBW 1YC0 2R0K 2R0L |
Descriptor | Hepatocyte growth factor activator long chain, Hepatocyte growth factor activator short chain, Antibody, Fab fragment, Heavy Chain, ... (6 entities in total) |
Functional Keywords | serine protease, allosteric inhibitor, antibody, egf-like domain, glycoprotein, fab complex, hydrolase, disulfide bond, kringle, protease, secreted, zymogen, hydrolase-immune system complex, hydrolase/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 79379.04 |
Authors | Ganesan, R.,Eigenbrot, C.,Shia, S. (deposition date: 2009-09-30, release date: 2009-12-15, Last modification date: 2023-09-06) |
Primary citation | Ganesan, R.,Eigenbrot, C.,Wu, Y.,Liang, W.C.,Shia, S.,Lipari, M.T.,Kirchhofer, D. Unraveling the allosteric mechanism of serine protease inhibition by an antibody. Structure, 17:1614-1624, 2009 Cited by PubMed: 20004165DOI: 10.1016/j.str.2009.09.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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